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SPG stimulation provides not only acute effectiveness but also reduces attack frequency.
Treatment is considered effective if it reduces attack frequency and/or severity by at least 50%%.
Waiting until 80 symptomatic cases reduces attack rates by 73%.
Imposing this strategy the day after 10 symptomatic cases reduces attack rates by 93% (Table 2).
At 90% compliance this strategy reduces attack rates by 20%<25%5% of infectious persons are influenced as pS × pH = 0.25 for adults only) (Table 2).
The drug FTY720 is an analog of S1P that interacts with the S1P1 receptor, and reduces attack frequency in patients with multiple sclerosis [ 13].
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The greater occipital nerve (GON) block reduces attacks in two thirds of patients with cluster headache [173].
Reduced attack surface.
Naproxen, taken on an as-needed basis, was helpful in reducing attack frequency.
The identification of trigger factors and their elimination, when possible, contribute to reduce attack frequency [218].
This prolonged treatment is necessary to reduce attack frequency and severity in migraineurs.
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