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Hydrochlorothiazide reduces adverse effects of furosemide upon the kidney concentrating ability.
This greatly reduces adverse effects including nephrotoxicity and allows delivery of large doses of the drug over short periods of time.
An SR formulation reduces this peak concentration and thereby reduces adverse effects and the frequency of administration and increases patient compliance.
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Pharmacogenetic testing raises the hope to individualize ACE inhibitor therapy in order to optimize its effectiveness and to reduce adverse effects for genetically different subgroups.
This strategy may increase compliance with effective protective agents, thereby reducing adverse effects in clinical practice.
A prospective study to define the most effective duration of TKI therapy and to reduce adverse effects is needed.
Employing tissue specific promoters (TSPs) to restrict transgene expression or viral replication is an effective way to increase specificity towards tumor tissues and to reduce adverse effects in non-target tissues such as the liver.
Treatments are often avoided during prenatal periods to reduce adverse effects on the developing fetus.
Delivering them directly to the tumor may improve therapeutic efficacy and reduce adverse effects.
Furthermore, the paper discusses application of steel fibers as an efficient additive to reduce adverse effects of restrained shrinkage.
Insulin reduced adverse effects of DM on OTM [15] DM diabetes mellitus, LLLT low-level laser therapy, OTM orthodontic tooth movement, TIMP tissue inhibitor of metalloproteinase.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com