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The more compact/rigid collabody structure reduces accessibility of the scFv modules [15], that is a critical parameter for tumor targeting in vivo.
Conversely, histone deacetylation increases chromatin compaction and thereby reduces accessibility of transcription factors to the DNA.
At this high concentration, Dan binds to DNA cooperatively and forms a rigid collaborative filament that causes DNA compaction into complex higher order structures and reduces accessibility (Fig 2D) (Lim et al, 2013).
Similar(57)
Proposals to address childhood obesity are often aimed at augmenting features of the environment by improving access to healthy foods in or around the home and school, reducing accessibility and exposure to unhealthy food, and/or providing more opportunities for exercise and vigorous play.
Reducing cohort size is tantamount to reducing accessibility.
For instance, one could expect higher quality to reduce accessibility, because it makes ECEC more expensive.
Regrowth of paths due to abandonment of seasonal farming has reduced accessibility.
Thus, by reducing accessibility for motorized vehicles, such a buffer zone, might increase accessibility for pedestrians and cyclists.
We focus in the following on causes that can reduce physical or sensorial abilities, and, consequently, can reduce accessibility, and we briefly outline corresponding guidelines to achieve accessibility.
While congestion can constrain mobility and reduce accessibility, traffic is also associated with agglomerations of activity and is thus a byproduct of proximity-based accessibility.
The root contact may have occurred due to the presence of narrower interradicular spaces in the mandibular arches and reduced accessibility in the mandibular posterior region [8],[8]].
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