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However, bicarbonate stays around in the bloodstream for longer, and further episodes of hypercapnia lead to relatively mild acidosis and reduced ventilatory response in a vicious circle.
These patients show reduced ventilatory muscle strength, as measured by maximal inspiratory and trans-diaphragmatic pressures.
An elevated PaCO2 during exercise generally represents pulmonary pathology with a markedly reduced ventilatory capacity.
The reduced ventilatory efficiency is therefore caused by an increase in physiological dead space and a reduced PaCO2 set-point [ 45].
Our data indicate that abnormally reduced ventilatory efficiency parameters are powerful and independent predictors of mortality in patients with PAH/CTEPH.
These effects are viewed as the pharmacodynamic basis of improved organ function: decreased renal failure [ 31], reduced ventilatory support [ 32], decreased infection rate [ 33] and reduced transfusion requirements [ 31].
Similar(46)
Despite limited studies to support its use, diuretics are commonly used to reduce ventilatory and oxygen requirements, and methylxanthines like caffeine are ubiquitous, due to the proposed beneficial short and long-term effects on respiratory and developmental status [42].
Mechanical ventilation by reducing ventilatory muscle activity turns off this process.
16 The second component consists of structured guidelines for reducing ventilatory support.
There is also evidence that mechanical ventilation reduces ventilatory muscle injury [ 51, 52].
These programs reduce lactic acid accumulation and hence reduce ventilatory requirement for a given level of exercise (24).
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