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The chemistry is a systematically reduced variant of the 48-species and 300-reaction C/H/N/O mechanism of Lindstedt and co-workers.
Instead, VASP provides powerful filters with the aim of allowing researchers to harness their additional knowledge of the disease to generate reduced variant lists suitable for manual interrogation.
This second, reduced variant provides less information on the ligands to be found in the ranking and consequently poses a more realistic but harder problem.
Glucuronate is an oxidized derivative (redox state = +2) of glucose (redox state = 0), while glucitol is a reduced variant (redox state = -1).
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Therefore, it can be proposed that avoiding the generation of certain combinations of β texture components during thermomechanical processing has the potential for reducing variant selection during subsequent β heat treatment.
If companies choose to limit complexity we suggest optimizing configuration rules, reducing variants or both.
For example, instead of automatically filtering (reducing) variants based on certain criteria such as minor allele frequency, variants are annotated and then an explicit filtering operation is applied.
Through qRT-PCR analysis, we confirmed reduced SMAD6 variant 2 mRNA expressions in all examined tumors, indicating HCC-specific down-regulation of variant 2 (Fig. 3b).
For example, CYP2C19*6 is a rare variant that results in negligible catalytic activity towards the universal CYP2C substrate tolbutamide, and is classified as a reduced activity variant similar to CYP2C19*2 and CYP2C19*3.
CHD2 depletion causes increased histone H3 and reduced histone variant H3.3 occupancy.
Table S3, we reduced the variant count to less than 15 in all cases.
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