Sentence examples for reduced trail from inspiring English sources
Although we are aware that a limitation of this exploratory analysis is the relatively small sample size examined, which does not allow to corroborate the prognostic relevance of TRAIL as a biomarker, several possible mechanisms by which reduced TRAIL serum/plasma levels might contribute to worsen the outcome of AMI can be envisioned.
Interestingly, IFN-α-neutralizing antibody reduced STAT1 activation (48% inhibition) and significantly reduced TRAIL expression levels, whereas IFN-β-neutralizing antibody treatment did not cause a statistically significant decrease in STAT1 activation or TRAIL expression (Fig. 6I, J).
Blocking signaling factors, including IRF-1, IRF-7, type I IFNs, or STAT1, significantly reduced TRAIL gene expression (Fig. 4, 6, 7).
The MDAMB-231 cells in which IRF3 and IRF7 were knocked down showed an elevated resistance to apoptosis and reduced TRAIL expression after polyIC transfection or NDV infection.
The poorest responding cells to combined treatment, MCF-7, developed self-renewing MFUs at very low frequency (1/12,000 cells seeded) in reduced TRAIL conditions.
This suggests reduction in lung damage in CCR2−/− mice may be due to reduced TRAIL ligand availability.
If the ORV community feels so strongly that they can't survive with a reduced trails budget, then what keeps them from self-imposing a special trails-dedicated annual vehicle fee separate from the state sticker fee?
In line, siRNA targeting c-Rel strongly reduced TRAIL-induced NFATc2 activity in TRAIL-resistant PDAC cells.
Inhibition of JNK activity in Colo205 cells reduced TRAIL-induced apoptosis, however enhanced agonistic DR4- (P=0.0002) and DR5 antibody-induced cell death (P=0.0006; Figure 3B).
On the other hand, knockdown of the long JNK1 isoforms (JNK1 α2 and JNK1 β2) had the opposite effect; it reduced TRAIL-induced cell death.
On the contrary, expression of Bcl-XL in HeLa or Jurkat cells substantially reduced TRAIL-induced apoptosis, indicating differential inhibitory activities of Bcl-XL and Bcl-2 in TRAIL-mediated cell death.
