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"One thing that we haven't been able to do is to design chemicals so that they have reduced toxicity, reduced adverse impact on humans and the environment.
Toxic to many plants at widely varying concentrations; reduced toxicity at pH > 6.0 and in fine textured or organic soils.
Lipid-based formulations of amphotericin B are thought to have reduced toxicity while retaining antifungal action.
Antibody-drug conjugates (ADCs) offer increased efficacy and reduced toxicity compared to systemic chemotherapy.
Of significance, both pyrrolidinedione analogs demonstrated reduced toxicity.
Pons, T. et al. Cadmium-free CuInS2/ZnS quantum dots for sentinel lymph node imaging with reduced toxicity.
Epirubicin has a different spatial orientation of the hydroxyl group at the 4′ carbon of the sugar, which may account for its faster elimination and reduced toxicity.
This latter has been reinforced by the low cost of melatonin and its reduced toxicity.
These transfection levels were equal or greater than achieved by Lipofectamine, with much reduced toxicity.
In addition, modification with mPEG reduced toxicity associated with intravenous administration.
The design of innovative anticancer chemotherapies with superior antitumor efficacy and reduced toxicity continues to be a challenging endeavor.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com