Sentence examples for reduced tolerability from inspiring English sources

Results of this study indicate a low risk for reduced efficacy and reduced tolerability in patients with hepatic impairment.

This minor protocol violation was initiated during the course of the study, following up several patients who experienced reduced tolerability and side effects (nausea, diarrhoea) when immediately starting on 80 mg daily.

Underconjugation can decrease potency of the resultant ADCs, whereas overconjugation can lead to decreased circulation half-life, reduced tolerability, and impaired antigen binding.

Management of other comorbidities, common in older patients and in those with other risk factors, will likely involve treatment with other medications and the burden of polypharmacy or reduced tolerability through interactions cannot be discounted.

However, these early response data were not mirrored in the subsequent objective response rates, determined using RECIST version 1.0 (earliest possible confirmed response at 12 weeks); this may be because of the reduced tolerability associated with cediranib and the subsequent reduction in mFOLFOX6 dose intensity.

It is not clear if the lower compliance was due to the reduced tolerability of AQ seen in other studies as the frequency of minor adverse events observed in all the treatments groups was similar.

In contrast, administering dry texture FS muffins seemed to reduce tolerability among oncology patients with xerostomia in Milby et.al. Oxidative stress biomarkers also trended lower in this trial.

C-terminal truncation of both peptides reduced salt-tolerability of the microbicidal effect as well as anti-inflammatory actions.

Rapid delivery of capsaicin may promote, rather than reduce, the tolerability of topical capsaicin.

The dose could then be reduced according to tolerability.

Additionally, this step-down strategy could have added benefits, such as better tolerability, reduced use of IV catheters, earlier patient discharge, and significant cost savings, as documented in oral step-down antibiotic regimens [ 5- 11], although prospective data for de-escalation in antifungal therapy are lacking.