Sentence examples for reduced to activate from inspiring English sources

These regulatory disulfides are reduced to activate and reform to inactivate the enzyme.

It is now well established that the activity of Ero1α is tightly regulated by the presence of non-catalytic disulphides that need to be reduced to activate the enzyme (Tavender and Bulleid, 2010a).

Yeast Ero1 (Ero1p) is also regulated by the UPR (Frand and Kaiser, 1998; Pollard et al, 1998) but, in addition, is regulated post-translationally by the formation of non-catalytic disulphides that need to be reduced to activate the enzyme (Sevier et al, 2007).

Microglial activation assessed by Iba1 + IR showed marked activation phagocytic morphology in the TD group, that was reduced to "bushy" activated microglial phenotypes in the GTA-TD group, but not to ramified "resting" morphology as seen in controls (Fig. 12 A, top).

Diabetic patients with autonomic dysfunction show reduced vagal tone combined with reduced ability to activate sympathetic tone [ 25].

The hypercoagulable state is due to enhanced intrinsic contact activation and reduced capacity to activate protein C. The coagulation system might be a useful additional therapeutic target to reduce the high recurrence rate of stent thrombosis.

Sequence differences in the PA region (possibly the 4 additional negative charges in the PA linker of muC0C1) are likely to be responsible for its reduced ability to activate the thin filament.

PdBD is a mutant version of PLY with less cytolytic activity and reduced ability to activate complement [ 29].

This common factor was hypothesized to involve a declining ability to inhibit task-irrelevant, default-mode activity, coupled with reduced ability to activate cognitive regions such as the DLPFC [26], [39].

While this manuscript was in preparation, Wu et al. reported an identification of a FGF19 variant with a dramatically reduced ability to activate FGFR4, but that was only modestly compromised for FGFR1c activation and retained the ability to acutely reduce blood glucose levels in ob/ob mice [17].

In addition, ORF4 mutant viruses with a reduced capacity to activate Akt showed the same phenotype, and activation of Akt by insulin was able to release this phenotype to a significant extent, thus providing further evidence for a role of Akt activation in promoting infection.