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Uncontrolled HIV infection may increase HR-HPV persistence through altered cell-mediated immunity, local molecular interactions and reduced tight junction function [ 25– 27].
Microvascular leakage and reduced tight junction protein expression are known to occur in ALS and could contribute to motor neuron damage.
A study by Abbruscato, et al., (2002) has previously demonstrated the direct dose-dependent effects of nicotine and cotinine on increased paracellular BBB permeability and reduced tight junctional protein expression, using bovine brain microvascular endothelial cells in culture, an in vitro BBB model.
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We conclude that MAPk signaling has the potential to modulate stretch-induced alveolar epithelial injury, and propose further studies should be conducted to identify opportunities for reducing tight junction disruption.
21 Tight INR control is necessary if stroke is to be prevented effectively and the risk of bleeding reduced, but tight control is sometimes difficult to achieve with warfarin.
After the recession hit in 2008, a series originally planned for eight hours was reduced by tight funds to six.
When claudin-1 is reduced, the "tight junctions" between skin cells become leaky and permeable to environmental allergens and infectious agents.
Results show that the pore length is reduced in tight chalks, with 140 nm on average in argillaceous chalk and 533 nm in cemented chalk, compared to 1091 nm in micritic reservoir chalk.
The risk of vascular complications can thus be greatly reduced by tight management of these risk factors [ 5- 8].
'Modern' CRRT, using higher effluent rates, will accentuate extracorporeal glucose losses that, on the other hand, can be reduced by tight glycemic control.
Trial evidence to date suggests that cardiovascular risk may be reduced through tight glycaemic control in individuals with diabetes [ 5, 6].
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