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Size scaling using NFM and allometry reduced the objective function more than either TBW or NFM.
The only covariate that statistically improved the base model was the presence of CRRT for CL, which reduced the objective function value by 5.774 (P <0.05).
Inclusion of dual linear and nonlinear elimination processes, in which the nonlinear elimination pathway was described by a Michaelis Menten model, improved the goodness of fit and reduced the objective function (δ = 97.43).
Inclusion of sex as a covariate for CL/ F of TAK-875 reduced the objective function value and IIV for CL/ F in the final model by 14.52 and 7.6% coefficient of variation units, respectively.
The model with parallel linear and Michaelis Menten elimination (MM model) and the model with time-dependent clearance both reduced the objective function (OFV) compared with a linear two-compartment model.
When two or more covariates are found to significantly improve the model, the covariate that reduced the objective function most is included in the model after which the other covariates are tested again for their significance.
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On 30 September, the general staff of the JNA reduced the objectives of the campaign because it had not followed the initial plan and had become bogged down.
Entries of the constraint matrix are negative for similar objects because they are rewords that reduce the objective function.
The reliability-based optimization approach aims to find the best design with a compromise between reducing the objective function (cost, weight, etc).
The article shows that it is possible to reduce the objective lens diameter two times without loss of resolution, and thus to improve impact resistance by reducing the probability of collision and objective lens cracking.
For Husserl, phenomenology would study consciousness without reducing the objective and shareable meanings that inhabit experience to merely subjective happenstances.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com