Sentence examples for reduced the binding from inspiring English sources

Third, the expression of MSH2Y238F substantially reduced the binding between NPM-ALK and endogenous MSH2, although the mutant itself can bind to NPM-ALK.

Underscoring the importance of these Erh1 residues, substitution of Erh1Asp27 or Erh1Arg23 with alanine significantly reduced the binding affinity of Erh1 for Mmi195 122 (Supplementary Table 1).

BMP-6 treatment significantly reduced the binding of these factors to miPPR-21 by decreasing the expression of δEF1 and c-Fos/c-Jun.

Consistently, METTL3 depletion reduced the binding of DGCR8 to pri-miRNAs and led to reduction of mature miRNAs and accumulation of unprocessed pri-miRNAs.

Mutations at residues D163A and N170R, on the other hand, reduced the binding affinity of Envgp120-C3d2 for sCR2.

Either the single base substitution of the DRE core sequence or point mutation of the key amino acid in TINY DNA-binding domain greatly reduced the binding strength.

The use of a comonomer (ACM or HEMA) reduced the binding performance of the MAA/EDMA polymer matrix, probably due to the monomer monomer association and morphological differences.

Mutation of residue 186 (F186L) dramatically reduced the binding capability of t-CD81, a result that has already been demonstrated for the human receptor, whereas the opposite mutation (L186F) in agm-CD81 resulted in a neat gain of binding activity.

In addition, the thermostabilization procedure had a significant impact on specific ligand affinities of the receptor and abolished or reduced the binding of certain antagonists.

Further, SUMO-1-conjugated Sox2 at the lysine 247 or at the carboxyl terminus reduced the binding to the Fgf4 enhancer.

Introduction of a fluorine atom onto the carborane cage commonly reduced the binding affinity for ERα, to an extent that depended on the other substituents present.