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It was also susceptible to clindamycin, and vancomycin, but had reduced susceptibility to gentamicin.
These mutations often involved similar or identical amino-acid changes that reduced susceptibility to the toxin.
Mindrescu, C. et al. Reduced susceptibility to collagen-induced arthritis in DBA/1J mice expressing the TSG-6 transgene.
Reduced susceptibility to the fluoroquinolone class of drugs and the emergence of multi-drug-resistance has complicated the treatment of infections, especially those acquired in south Asia.
Conclusions: We have determined three novel alterations in HCMV DNA polymerase inducing reduced susceptibility to PFA.
The reason for reduced susceptibility may be associated with other structural differences between MecA and MecD, e. g. the diverse nPBDs.
In vitro, these events were associated with defective lysis and reduced susceptibility to tPMP.
Furthermore, treating zebrafish with a cholesterol-lowering agent, ezetimibe, reduced susceptibility to S Typhi.
The 12 fecal samples had reduced susceptibility to one or more carbapenems according to CLSI guidelines 2012 using disk diffusion, 12 (100%) of isolates had reduced susceptibility to imipenem while 11 91.7%) had reduced susceptibility to meropenem.
However, these agents drive selective pressure for mutant viruses that can develop rapidly and have reduced susceptibility to the drug.
All the 12 positive isolates by Chrom agar-KPC and or MHT and PCR had reduced susceptibility to imipenem by disk diffusion while 11 (91.7%) of them had reduced susceptibility to meropenem by disk diffusion method (Table 5).
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