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This subgroup analysis did not alter effect sizes, however, it reduced study power to identify those effect sizes as significant.
Finally, those who had discontinued permanently or reduced study medication did not reach PO sooner than those who did not.
Estimates for the hospital-level analyses are unstable especially as considerable inter-country differences necessitated stratified analyses and thus reduced study power.
Early and ongoing data monitoring is especially important for multicenter studies, in which differences between centers can lead to bias and reduced study power.
Significant effects were only found for female students who additionally reported reduced study stress and an increase in the mindfulness facet 'non-judging'.
The failure to meet the trial target recruitment was due to a contractually fixed end date for the trial and the 109 participants providing 4 week data reduced study power to 47%.
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(F ) Reduced study-dependent relationships between mRNA responses and either 3′-UTR length or 3′-UTR AU content.
Although creatine kinase levels were reduced, studies have questioned the involvement of creatine upon finding deposits of the molecule in amyloid precursor protein (APP) in transgenic mice.
Such type of design may reduce study drop-out rates and thereby, associated costs and timelines.
Capturing long-term outcomes from large clinical databases by use of claims data is a potential strategy for improving efficiency while reducing study costs.
Furthermore, such quantitative outcomes, especially when measured precisely, can, dramatically reduce study sample size needs and facilitate timely assessment of neuroprotective interventions [58].
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