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In a longitudinal study, Sharp and colleagues demonstrated a reduced structural damage in RA patients under leflunomide therapy; both study cohorts (MN302 und US301) showed increased values of up to 1.48 for leflunomide and up to 1.08 for methotrexate estimated by means of the Sharp Score for joint space narrowing [ 22].
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The Asymmetric Friction Connection (AFC) was developed to create a repeatable, efficient means of dissipating seismic response energy and reducing structural damage without yielding of structural frame elements.
This combination can reduce structural damage that could be caused by seism, and it remarkably enhances the anti-seismic capability of structures.
In terms of fire resistance, the right choice of a construction material plays a key role and can reduce structural damage or even save human lives.
Such devices on one hand must allow for a sufficiently high level of structural decoupling and energy dissipation in order to reduce structural damage, and on the other hand must provide enough stiffness in order to prevent excessive deformations or residual offsets.
Rather the groupings, categorized by occupancy or use, are used to establish design criteria intended to produce specific types of performance in "design earthquake" events, based on the importance of reducing structural damage and improving LS (Fig. 1).
Targeting the cell-bound and soluble IL-6R using monoclonal antibodies has proven to be an efficacious therapy in RA, significantly reducing structural damage [ 5].
Of interest, oxaliplatin treatment can reduce structural damage and inflammation in murine CIA as long as extracellular HMGB1 expression is low due to therapy [ 53].
Demyelination, as determined by Luxol Fast Blue staining, was also reduced by anti-CD20 (0.20 ± 0.03 mm vs. 0.33 ± 0.05 mm) showing that the treatment reduces structural damage (Fig. 2B and C).
Although TNF-blocking drugs have been extremely effective in improving clinical outcomes and reducing structural damage, there is the concern of the increased risk of serious infections and malignancies.
The observation that blockade of JNK reduces structural damage in collagen-induced arthritis – an autoimmune-triggered model of RA that does not exclusively depend on TNF – supports this idea [ 31, 32].
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CEO of Professional Science Editing for Scientists @ prosciediting.com