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All variants had reduced specificity for DHB.
Expression of R133C protein from an integrated transgene in embryonic stem cells also revealed reduced specificity for methylated DNA (24).
Similarly, in the presence of jaundice, markers showed reduced specificity for PDAC patients over benign subjects with jaundice.
Weaker amino acid affinities imply that the Urzymes likely have reduced specificity for their cognate amino acids.
Improvements in assay sensitivity have inevitably reduced specificity for myocardial infarction, as these assays do not define the cause of myocardial injury.
MCMs can be expressed in cells showing reactive features (Williams et al, 1998), and whereas the morphology of reactive cells can generally be identified by experienced observers, any algorithms that did not take such information into account would generate reduced specificity for disease detection.
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thus reducing specificity for the original targets [ 33].
Within this set of mutations, two reduce specificity for NADP by 6000-fold, whereas the rest enhance NAD usage 200-fold.
Other syndromic surveillance systems do not use a definition but analyse the total volume which is reducing specificity, for example systems using school absenteeism data [ 35, 50, 51].
Elevated CgA levels are found in cardiac, endocrine and inflammatory diseases, thereby significantly reducing specificity for pNETs (Modlin et al, 2010).
There are reports of β-lap inducing caspase-mediated apoptosis, but this is noted only after long-term continuous treatment with β-lap, which also reduces specificity for NQO1+ overexpressing cells.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com