The fact that total lymphocytes and non-HCV-specific T cells are reduced specifically in those with a subsequent SVR, but recover after treatment stops in spite of undetectable viraemia, suggest that the decline in HCV-specific T cell responses has little to do with changes in HCV viral load.
Using RNA interference (RNAi) technology, the levels of a toxic phytoprotectant have recently been reduced specifically in the seeds of cotton to generate a novel dual-purpose crop.
The addition of NM to the soil solution reduced specifically the concentrations of available As and Cd, but the TE-adsorption capacity of NM decreased as the P concentration increased.
Moreover, using a cationic lipid reagent, the siRNAs were efficiently introduced into leukemia cell lines with t(8 21), SKNO-1 (30 40%) and Kasumi-1 (60 70%) cells, and reduced specifically the endogenous AML1 MTG8 expression.
In Lrp4 mutants, Ptc1 and Gli2 were found to be slightly downregulated in the epithelium of junctional region (Figures 7M' and 7N'), suggesting that Shh signalling is reduced specifically in this epithelium.
Human pharmacodynamic studies demonstrated that letrozole reduced specifically and markedly plasma concentrations of estradiol, estrone and estrone sulfate.
