Sentence examples for reduced signalling from inspiring English sources
Here, we report a profound effect of aging on the frequency and immunosuppressive function of transitional CD19+CD24hiCD38hi and CD19+CD5+CD1dhi B10 B cells, resulting from both a lack of T cell help due to reduced upregulation of CD40L upon activation and reduced signalling through CD40 on the B cell.
Reduced signalling through the insulin/IGF-like (IIS) and Target of Rapamycin (TOR) signalling pathways also extend lifespan.
Reduced signalling through the insulin/insulin-like growth factor-1 signalling (IIS) pathway is a highly conserved lifespan determinant in model organisms.
Through a mechanism that was unrelated to ATP production, the interruption of mitochondrial fusion reduced signalling calcium entry, which suppressed calcineurin activity and Notch signalling (Kasahara et al., 2013).
Reduced signalling through the NF-κB and MAPK pathways followed by restored insulin-stimulated Akt phosphorylation provide a mechanism for the ability of TAK-242 to protect against LPS-induced insulin resistance.
However, reduced signalling through the IIS pathway is also associated with increased lifespan and healthspan in model organisms (Clancy et al., 2001; Holzenberger et al., 2002; Barbieri et al., 2003; Tatar et al., 2003; Giannakou & Partridge, 2007; Piper et al., 2008; Selman et al., 2008; Vallejo et al., 2009; Kenyon, 2011; Selman et al., 2011).
Likewise forced expression of Xpcl1 in cultured cells reduced both Tgfbr2 mRNA levels and reduced signaling downstream of TGF-ß.
In EBs treated with RA, HS chain depletion reduced signaling via all these pathways as compared with untreated EBs.
Reduced signaling via the Hippo pathway results in increased activity of the transcriptional co-activator Yki.
18 Obesity is associated with "leptin resistance", ie, reduced signaling through leptin receptors.
These alterations should include reduced signaling through growth-suppressing pathways and/or enhanced signaling through growth-promoting pathways.
