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However, GASP-1 KO mice exhibited significantly reduced sensitization that also developed more slowly compared to WT mice.
However, given the multitude of inhibitory effects of Bay 11-7082, is is difficult to ascertain whether the increased or reduced sensitization to PDT is the result of NF-κB inhibition or of impaired AP-1 activity.
Interestingly, we observed a reduced sensitization capacity of nOVA upon oral antigen administration.
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The importance of this sensitizing mechanism is underscored by the ability of prostaglandin synthesis inhibitors to reduce sensitization.
Research leading to mechanistic descriptions of migraine-related acute CA and interictal WPH may lead to treatments that more effectively reduce sensitization and its clinical consequences.
Changes in trunk neuromuscular control following HVLA spinal manipulation may reduce sensitization or muscle fatigue effects related to repetitive movement.
Furthermore, a recent study from South Africa indicated that Ascaris may have dual effects, being able to both enhance EIB development and reduce sensitization to inhalant allergens [ 29].
The present results indicate that changes in trunk neuromuscular control following HVLA spinal manipulation may reduce sensitization or muscle fatigue effects related to repetitive movement.
Baclofen treatment facilitated the extinction of COR and reduced conditioned sensitization during extinction when given after, but not before, the activation of the CPP memory trace.
This concept may represent a mechanism underlying reduced pain sensitization and opiate tolerance phenomena.
Our results provide evidence that Ser307 phosphorylation was induced in Abcd1 − compared with wild-type (Wt) mice, suggesting reduced insulin sensitization in X-ALD pathology.
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