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Cells with reduced topoisomerase IIα showed reduced sensitivity to voreloxin-induced G2 arrest.
This reduced sensitivity to imipramine may explain the reduced responsiveness of patients with geriatric depression to the therapeutic effects of imipramine and other tricyclic antidepressants.
Alternatively, if reduced sensitivity independently arises, we expect to find reduced sensitivity in different populations consisting of different clonal genotypes.
The HRC has strongly reduced sensitivity in this spectral region, as shown in Figure 7.16.
Reduced sensitivity to linguistic context in schizophrenic thought disorder: evidence from on-line monitoring for words in linguistically anomalous sentences.
Other groups have utilized chemical exchange saturation transfer (CEST MRII techniques which can have reduced sensitivity on low-field (≤ 3 T) MRI scanners34,35,36.
Consistent with this, mutations in HDAC6 (and1-4) and HDAC19 (hda19), which lead to increased genome-wide histone acetylation25,26, reduced sensitivity to high-B stress (Fig. 9c).
Regardless of the signal amplitudes, all constructs exhibit reduced sensitivity for chloroquine as evident from the right-shifted dose-response curves.
Mature seeds of ger5-2 mutalso also exhibit reduced sensitivity to ABA during seed germination assays.
Reduced sensitivity to cathode deformations (due to internal overpressure as mechanical strain) is directly demonstrated.
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The sensor with TiO2 (90 nm) shows reduced sensitivity-threshold and improved linearity.
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