The analytical functions for the optimisation were chosen as the one that produced the best agreement, for each given reduced sampling protocol, with the original blood fits.
Extending the satellite data over 6 years (2001 2006) reduced sampling errors.
The GLMM maximum likelihood procedure is a full information estimation procedure that uses all data present at each assessment point, which reduced sampling bias associated with participant attrition.
Based on existing activity measurements, a reference and reduced sampling schedule ("case") were generated.
Generally, different filter designs would be considered for acquisition (h A (n)) and tracking (h T (n)) stages, for implementing reduced sampling for the acquisition process.
We then assessed whether test-retest variability and accuracy for determination of proliferation of the population input functions were affected by this reduced sampling population-based methodology.
This paper examines the nature of the required filters, and presents a method of adapting those filters to suit reduced sampling rates.
It was observed from both reduced sampling frequencies that the error level was comparable to the usual accuracy of a DLT 3-D reconstruction technique.
In this study, we investigated the consequences of using a population input approach and highly reduced sampling protocols to estimate FLT kinetics in oncology PET studies without continuous arterial sampling.
To evaluate the effect of sampling on individual treatment planning, reduced sampling schedules were generated omitting either 1, 2, 3, or 4 organ and serum measurements or all serum measurements for each patient.
A filter, based on experimental data sampled at a high sampling rate, is adapted to suit reduced sampling rates, and the effectiveness of the adapted filters is demonstrated with experimental data.
