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A previous study did not find a generally reduced responsiveness as well because false positive responses and omissions counterbalanced each other [ 27].
This reduced responsiveness cannot be explained by tolerance.
Reduced responsiveness of the β-cells to glucose is a critical feature of this syndrome.
Those who had episode recurrences during the discontinuation were more likely to show reduced responsiveness upon re-treatment.
Reduced responsiveness to isoprenaline by PDGF was also not observed in the presence of Ca2+-free solution.
Resistance to thyroid hormone (RTH) is a genetic disease associated with mutations to TRβ that lack or show reduced responsiveness to thyroid hormone (triiodothyronine).
We started with a clone of rat insulinoma cells (S4 cells), which showed reduced responsiveness to glucose in terms of insulin secretion.
Finally, PD myoblasts showed reduced responsiveness to T stimulated mRNA expression of mTOR vs. CON cells and T also reduced myostatin expression in PD myoblasts only.
"Reduced responsiveness that reverses with sufficient stimulation to cause waking is another important criteria that allows us to consider this to be a sleeping behavior," Dr. Miller noted.
GPCRs that undergo desensitization display reduced responsiveness to a second stimulation with the same agonist [28].
Biglycan deficiency also causes reduced responsiveness to TGFbeta among osteolineage cells [25].
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CEO of Professional Science Editing for Scientists @ prosciediting.com