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This suggests that a pool of partial or reduced resistant strains may persist long after antibiotics disuse, which is consistent with Enne et al. [ 17] reporting the persistence of resistant E. coli 8 years after reduction of antibiotics use.
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The finding that non-specific interventions, such as hand hygiene, are more effective at reducing resistant rather than susceptible organisms when resistance is rare in the community is also consistent with predictions from mathematical models.
The FDA's ban on fluoroquinolones in poultry production may be insufficient to reduce resistant Campylobacter in poultry products.
A counteracting factor to this concern is the effectiveness of PCV in reducing resistant strains of Streptococcus pneumoniae [ 16, 17].
Another possibility to reduce resistant variants is the combination of two or more RNAi molecules with different specificities [ 125] targeted to separated regions of the HCV genome.
Both strains were resistant to acid and bile and reduced vancomycin resistant Enterococcus (VRE) intestinal colonization when administered orally with the two bacteriocin-producing cultures or the P. acidilactici M33A, a mutant without the capacity to produce bacteriocin.
These factors were reduced in resistant carcinomas.
In fact, in our study the micro-vessel density and several angiogenic factors were reduced in resistant NSCLC.
Of the pro-apoptotic factors investigated FAS/CD95, FAS ligand, and caspase-3 only FAS/CD95 was significantly reduced in resistant NSCLC.
Silymarin-rich milk thistle extract (MTE) and its component silibinin enhanced alkaline phosphatase activity of osteoblasts but reduced tartrate-resistant acid phosphatase (TRAP) activity of osteoclasts.
Although new molecular diagnostic tests such as GenoType MTBDR plus and Xpert® MTB/RIF have reduced multidrug-resistant tuberculosis (MDR-TB) treatment initiation times, patients' experiences of diagnosis and treatment initiation are not known.
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