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Since 1993, the beneficial effects of interferon beta have been shown [ 1], and in Japan, interferon beta-1b (IFN beta-1b) has significantly reduced relapse rates and reduced MRI lesion areas in patients with relapsing-remitting MS [ 2].
Of interest, the reduced relapse risk after ASCT translated in better disease-free survival in the 300 rapid responders who reached CR after the first induction course.
Much of the success is due to the improvements in leukaemia therapy demonstrated in improved disease-free survival and reduced relapse rates in clinical trials but improvements in supportive care over the years have also had a very significant contribution.
These data suggest that prophylactic DLI followed by MRD test and GVHD-guided multiple DLIs reduced relapse and increased survival post-transplant in patients with refractory/relapsed acute leukemia who received allo-HSCT.
The two new studies, published online in The New England Journal of Medicine, found that the drug BG-12, developed by Biogen Idec, reduced relapse rates in patients with relapsing M.S. by about 50 percent.
Argon beam coagulation and electrocoagulation to destroy the remaining epithelium and placement of an omental transposition flap after fenestration can also contribute to reduced relapse rates [25].
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Reduced relapse-free survival was seen in the breast and lung carcinoma datasets while reduced lung and bone metastasis-free survival was observed in two other breast tumor datasets.
Patients with CK+ cells in the bone marrow had a reduced relapse-free survival, but the difference was not statistically significant.
Low AR expression in ER-positive breast cancer has been associated with significantly reduced relapse-free and overall survival (Peters et al, 2009).
Moreover, we observed that higher levels of PLAU mRNA correlate with a reduced relapse-free survival in breast cancer patients, as previously reported for its encoded protein uPA.
In recent follow-up studies, GPER has been shown to be correlated with reduced relapse-free survival in patients undergoing TAM treatment (Ignatov et al. 2011).
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