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Use of the Milan, size-based criteria, has reduced recurrence rate to less than 10% but many patients remain ineligible.
Five-year follow-up trial data confirmed a reduced recurrence rate (from 11to6%6%), still with no survival benefit (Peeters et al, 2006).
The better survival and reduced recurrence rate is not observed for patients with UICC stage I, with only a slight improvement in overall survival, which was not significant.
In later reports improved outcome from adjuvant 5-fluorouracil in terms of reduced recurrence rate and better overall survival related to patients with microsatellite stable tumors only [ 2, 5, 12, 29, 31- 33], whereas the subset having MSI cancers gained no similar beneficial effect from chemotherapy [ 11].
In a phase III clinical trial, oral fidaxomicin was as effective as oral vancomycin for the treatment of CDI but was associated with a significantly reduced recurrence rate (13% vs 24%), presumably because it caused less disruption of the anaerobic microbiota [ 12].
They found that cases with hypermethylation of p16 had a threefold higher risk for disease recurrence (RR = 3.3), whereas p14 methylation was significantly associated with reduced recurrence rate (RR = 0.109).
Similar(51)
The addition of trastuzumab to standard chemotherapy has dramatically reduced recurrence rates and improved survival in women with HER2-positive tumors.
Mesh reinforcement in cystocele repair has become popular in recent years, with some evidence of reduced recurrence rates.
The addition significantly increased the clinical and pathological response rates, but the initial data showed no significant impact on event-free or survival rates, although it significantly reduced recurrence rates.
In other studies, this has reduced recurrence rates compared with non-mesh surgery and extrusion rates when compared with vaginal mesh surgery.
Fighting spirit (one study [ 4]), stressful events (two studies [ 13, 25]), denial (one study [ 4]) and expressive activities (one study [ 9]) significantly reduced recurrence rates.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com