Sentence examples for reduced receptor from inspiring English sources

Reduced receptor function in people harbingers the onset of adult diabetes.

Moreover, proteasome inhibitors reduced receptor internalization and degradation, thus implicating a role for the ubiquitination machinery in the trafficking of the β2AR.

Mutation of a residue in M2 of the α subunit strongly reduced receptor modulation by SJM-3 and a homologous mutation in the β subunit abolished potentiation.

In swine with pre-existing atherosclerosis, the PPAR-β/δ agonist GW0742 failed to attenuate septic shock-induced kidney dysfunction and organ damage, most likely due to reduced receptor expression associated with cardiovascular and metabolic co-morbidity.

In swine with pre-existing atherosclerosis, the PPAR-β/δ agonist GW0742 failed to attenuate septic shock-induced circulatory failure and kidney dysfunction, most likely due to reduced receptor expression coinciding with cardiovascular and metabolic co-morbidity.

As a second step to improve vaccine safety, an additional mutation (W1266A) was engineered in the ganglioside binding pocket, resulting in reduced receptor binding, to produce M-BoNT/A1W M-BoNT/A1W

Using hemadsorption assays, it has been shown that mutated HN, generated in transduced cells, shows both reduced NA and reduced receptor-binding activity [ 3, 13].

As expected, clathrin-repression in these clathrin knockout cell lines significantly reduced receptor-mediated endocytosis.

Down-regulation of clathrin-expression generally results in a severely reduced receptor-mediated endocytosis [5], [10], [11], [12], [13], [14], [17].

These data suggest that the acute decrease in saliva secretion after radiation may be due to a reduced receptor-effector signaling.

Apart from an abnormality of EGFR or its ligand, a diminished EGF-EGFR interaction affinity and reduced receptor-associated tyrosine kinase activity caused by phosphorylation of EGFR threonine residues through protein kinase C (PKC -dependent [ 40] or indePKC -dependentys [ 40] may be speculated as the mechanism or Tyr1045 hypophosphorylatindependentcells.