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Blendy and colleagues have recently generated an α1D-deficient strain and have reported that these mice show reduced rearing responses in a novel cage and reduced nocturnal wheel running in the home cage (Saldalge et al, 2002).
TTC9A−/− animals consistently showed anxiety in the open-field test with increased immobility duration and time-spent in the corner zone (C,F); as well as increased immobility and reduced rearing frequency in the novel-cage exploration test (G,H).
The post hoc test revealed that diazepam reduced rearing time compared with all of the other treatment groups (P < 0.05).
In SCT these doses also reduced rearing significantly compared to controls, while only the 200 mg/kg dose significantly increased number of squares crossed at the center in the OFT test.
The present study showed that exposure of the experimental animals to the essential oil of F. vulgare significantly reduced rearing activity at doses (100 and 200 mg/kg) that did not suppress climbing, aligning with a behavior of an anxiolytic compound in a staircase model [ 47].
Reduced rearing activity was the only decrement observed in the hydrocephalic rats, with the exception of the dextrose-treated group, which paradoxically had the most severe ventriculomegaly.
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Only GABA receptor complex active agents have been shown to reduce rearing at doses that do not reduce climbing in the SCT.
As showed), although there was a tendency for rimonabant (10 mg/kg) to reduce rearing this reduction did not result significant.
We limited temperature shifts to adult flies (i.e., instead of rearing flies at three temperatures) to reduce rearing effects that could lead to differences in MEN activity or overall metabolism and possibly confounding our results.
The tests, which were conducted on taxis and telephone-company cars, showed that the lights reduced rear-end collisions by more than 50%.
Forward collision warning (FCW) systems can reduce rear-end vehicle collisions.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com