Sentence examples for reduced potency from inspiring English sources

The partial AR agonist Andrenosterone showed reduced potency of target engagement, with an EC50 of 50.6 nM.

However, these approaches suffer from rapid clearance and reduced potency over time.

LDN-193189 was the most effective drug in 3D cultures, with only slightly reduced potency compared to the 2D cultures.

The cellular pharmacology study indicated that the HDAC-inhibitor-drug conjugates retained antimitotic and proapoptotic activity with a reduced potency.

These conjugates showed reduced potency relative to unconjugated ASOs unless the lipophilic tail was conjugated to the ASO using a biocleavable linkage.

N-Terminal capping by acetyl eliminated PAR-2 activity, although removal of the amino group reduced potency by just 4-fold.

One of the gem-chlorines on the fused cyclopropane moiety of 2 was eliminated to produce 3, which showed reduced potency for iNOS inhibition, as well as 4 with an increased potency.

All the peptoid analogs reduced potency significantly, as well as most of the members of the N-methyl library, suggesting that the backbone conformation and/or hydrogen bond interactions of PTR6154 derivatives are essential for inhibition activity.

Inhibition by thiophosphorylated I-1 established that dephosphorylation does not play a significant role in I-1's reduced potency as an inhibitor of Mn2+-dependent PP1.

But a 2012 study suggested that the antibodies would have reduced potency if made in CHO cells.

Although the lactams were more efficiently absorbed and possessed enhanced chemotaxic antagonism, they also had reduced potency.