Exact(14)
HSC from mice lacking CD45 show reduced mobilization, impaired ability to cross extracellular matrix barriers, and a hyperadhesive phenotype.
Reduced mobilization and increased apoptosis, resulting in a shorter half-life of CPCs, can result from chronic exposure to inflammatory cytokines.
Not only impaired function but also reduced mobilization from the BM to the PB has been documented [ 22, 24] in diabetic patients.
Other major mechanisms by which liver damage arises in NAFLD/NASH are accumulation of lipids due to increased synthesis, reduced mobilization of fatty acids from lipid droplets, and cholesterol accumulation (56, 57).
We recently presented evidence of further reduction in net capillary fluid absorption as well as reduced mobilization of venous capacitance blood (capacitance response) in men with type 1 diabetes with microvascular complications (18).
Interestingly, anti-VEGF receptor 1 antibody reduced mobilization of bone marrow derived myeloid progenitors into the peripheral blood, suggesting that part of the mechanism of action in that study was impairment in leucocyte infiltration.
Similar(46)
During the transition period, the traditional management of dairy farm provides cows stress free environment, which directly reduce mobilization or circulation of NEFA from the adipose tissue; NEFA concentration directly reflect mobilization of adipose tissue, these fatty acids circulate in the blood to maintain energy balance during the transition period (McNamara 1991).
Glucocorticoids cause immunosupression by inhibiting the phagocytic function of alveolar macrophages and neutrophils, thereby reducing mobilization of inflammatory cells into infected areas.
Two hypotheses have been discussed to explain underlying mechanisms: First, smoking-related ROS production may decrease the bioavailability of nitric oxide (NO), thereby reducing mobilization of PCs from the bone marrow [ 26, 27].
Grk6-null mice display markedly reduced neutrophil mobilization from the bone marrow to the peripheral blood in response to G-CSF in spite of having normal hematopoiesis.
In a model of TNF-induced acute hepatitis, MMP-8 deficient mice showed dampened levels of PMN infiltration into the liver that was postulated to result from reduced LIX mobilization from an unidentified binding protein in the matrix [38].
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