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A specific patient may have reduced liver function which places her at greater risk of harm if she receives a treatment metabolized by the liver.
Together, these changes resulted in toxic accumulation of bile salts, reduced liver function and failure to thrive.
Moreover, reduced albumin concentrations in the sera of patients suffering from liver disease and/or reduced liver function may enhance the toxicity of the increased bilirubin levels.
The combination of sorafenib and GdCl3, but not each agent alone, attenuated liver fibrosis and significantly reduced liver function and hydroxyproline (Hyp).
This is partly because, unlike in the Ishizuka's report, in our study we enrolled patients not eligible for surgical resection: with more advanced stages of the disease and reduced liver function.
Our study demonstrated that GPS is associated with tumor progression and reduced liver function and can be considered as an independent marker of poor prognosis in patients with HCC in various stages of disease and different liver functional status along with the CLIP score.
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Recently, Zhang et al. (2013b) showed that DR reduced liver pathology and improved liver function (lower plasma levels of alanine amino transferase and alkaline phosphatase) in Sod1−/− mice, which exhibited increased liver pathology.
In the absence of GrzM, we observed enhanced survival following Listeria challenge, and this was associated with a reduction in liver-specific NK cell recruitment, augmented effector function of NK cells in the liver and reduced liver pathology.
However, once PVE has been performed, right hemihepatectomy is unavoidable because of reduced right liver function and a foreign body in the right portal vein; therefore, the decision to perform PVE should be made carefully and requires proof of no remaining intrahepatic bile duct expansion and bile production of the left liver after PTCD.
This program had the capability to show the time course of all liver tests for individuals who had both hepatocellular injury and reduced whole liver function, plus clinical narratives to diagnose the severity and most likely cause of the abnormalities.
In this study, probiotics were shown to reduce liver injury and improve liver function tests [ 31].
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