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Both graft types reduced LID compared with sham surgical controls.
Use of a lid clamp reduced lid contour abnormalities (OR 0.65, 95% CI 0.44 to 0.98) and granuloma formation (OR 0.67, 95% CI 0.46 to 0.97).
Consistent with published data (Eissenberg et al. 2007; Lee et al. 2007; Secombe et al. 2007; Lloret-Llinares et al. 2008), reduced LID led to increased global H3K4me3 levels.
Interestingly, grafts containing wild-type dopaminergic neurons reduced LID more than grafts containing DATKO dopaminergic neurons; and (v) Both wild-type and DATKO grafts induced a similar downregulation of PEnk, fosb/Δfosb and NMDA in striatal neurons of lesioned, l-dopa-primed dyskinetic rats.
The exclusion of rotational behavior from the dyskinesia score explains the reduced LID score for the 30-week-old MitoPark group as well as the lack of significance in the comparison to saline-treated MitoPark mice.
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Indeed, selective nicotinic acetylcholine receptor partial agonists can reduce LID, while extending the duration of motor benefits in nonhuman animal models of PD [1, 2].
To reduce lid contamination, we only cultured the bulbar conjunctiva where the instruments would be introduced.
Additionally, we found that absolute and relative kidney weight and quadriceps weight were significantly reduced in LID mice when compared to controls.
Increasing Ra reduces the lid thickness as well as the lid slope (Figure 5).
The curved lid reduced the size of the satellite droplet by gradually removing the top surface from the fluid droplet, while maintaining the one-direction swipe operation of the device.
Here the sky has been expunged, or reduced to a coffin lid that abruptly shuts on these subterranean men.
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