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One of the major results of molecular population genetics studies in islands has been that populations of endemic species often show reduced levels of variation in comparison with continental populations (deJoode & Wendel, 1992; Frankham, 1997), a situation frequently attributed to the founder effect (Frankham, 1997; Whittaker & Fernández-Palacios, 2007; Templeton, 2008).
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A few studies have documented reduced levels of genetic variation in declining populations of birds of prey (e.g., [98] [100]).
Taken together, highly reduced levels of genetic variation in introduced L. leucozonium populations along with significant bottleneck tests and lack of population structure suggest that this bee experienced a single and severe founder event during its introduction to North America.
The interaction between inbreeding depression and reduced levels of genetic variation will critically limit evolutionary responses.
Reduced levels of genetic variation can accelerate the emergence of inbreeding effects and limit a population's ability to adapt to novel conditions in the future (Futuyma 2005; Willi et al. 2006).
Areas that have recently experiences strong bouts of selection or where landrace populations tend to repeatedly go through periods of low population size (e.g., due to farmer seed management or field size), could have reduced levels of genetic variation within populations (i.e., genetic bottlenecks).
Theory indicates [ 9] and comparative studies across 170 species have shown [ 10] that a significant proportion of endangered populations/species have reduced levels of genetic variation compared to related non-endangered species, suggesting that genetic factors often play a role in population extinctions [ 11].
In addition to studying cells with artificially reduced levels of LEDGF/p75 expression, we were interested in natural variation in cellular LEDGF/p75 expression levels.
The BAT-gal transgene reporter of canonical Wnt signaling showed reduced levels of expression in Pygo1-/-/ Pygo2-/ mutants, with tissue-specific variation in degree of diminution.
CTT variation can provide MT specializations, for example, insects with unusual axonemes show reduced levels of both polyglutamylation and polyglycylation [ 39, 59].
Reduced levels of anti-P.
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