Sentence examples for reduced internalization from inspiring English sources

Molecules lacking one of these interactions showed other modes of action resulting in weaker binding or dramatically reduced internalization rates [31].

As an alternative approach we transiently transfected in FRT cells a siRNA directed against the clathrin heavy chain (CHCsiRNA)[67] which resulted in an efficient reduction of detectable clathrin as well as reduced internalization of PrPC and Tfr in transfected cells (Figure 3A and Table 1).

Among the various inhibitors we have tested, we found that the lipid raft inhibitor (mβCD), Lyn tyrosine kinase inhibitor (PP2), Akt inhibitor, and NF-κB inhibitor effectively blocked adhesion and internalization of P. aeruginosa, whereas the ceramide inhibitor (blocking sphingolipid pathway) only reduced internalization without affecting adhesion (Figure 2G, Table 1 and Figure S2B).

MonA reduced internalization moderately, and EIPA strongly.

The longer half-life of MM07 may therefore reflect reduced internalization as indicated by our in vitro assays.

This is consistent with our in vitro assays showing MM07 causes reduced internalization compared with [Pyr]apelin-13.

For example, Coleman (1989) has argued in favor of reducing internalization to rational choice, insofar as it is in the interest of a group to get another group to internalize certain norms.

Single receptor labeling of α7-nAChRs with QDs (QDOT®s; Invitrogen) was done at 4°C to reduce internalization and unspecific staining of QDs, as follows: Living cells were incubated with biotinylated α-BT (50 125 nM) in cell-conditioned medium for 5 min at 37°C/5% CO2.

Figure 7 figure supplement 1, shows that these compounds cause only a mild reduction in cell surface binding, but instead reduce internalization.

We were able to show that i) clathrin or CAV1 inhibition/interference blocks IGF1R internalization, ii) IGF1R signaling in ES largely depends on receptor internalization, and iii) the pro-survival and anti-apoptotic effects of IGF1R signaling are considerably reduced when internalization is blocked.

Moreover, proteasome inhibitors reduced receptor internalization and degradation, thus implicating a role for the ubiquitination machinery in the trafficking of the β2AR.