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Specific mechanisms explaining why serine phosphorylation leads to reduced tyrosine phosphorylation have not been completely identified, but candidates for this are reduced interaction of IRS proteins with the insulin receptor [ 11] and increased degradation of IRS [ 12, 13].
Contributing factors pertain to (1) reduced interaction of neutrophil granulocytes with brain endothelial cells linked to reduced circulating leptin levels and (2) an attenuated inflammatory response of the brain as reflected by changes in several inflammatory markers including inflammatory transcriptions factors namely NF-IL6.
The combination treatment of pUC +IR again reduced interaction of p-FAK with Grb2 when compared with pSV+IR in IOMM-Lee (55%), CH-157MN (40%) and in nude mice (90%) (Fig. 3D, E).
λ phosphatase markedly reduced interaction of 14-3-3 14-3-3 14-3-3sessed using the overlay assay.
Although the Ts mutants of Pam16 showed a compromised heterodimer subcomplex formation, a significantly reduced interaction of Pam18 at the translocon was observed, but Pam16 association remained unaffected (36).
The possible consequences of decreased GAGs are reduced interaction of several biofactors such as growth factors, coagulation factors, chemokines, adhesion molecules, and lipoprotein lipase with HSPG in the vasculature [ 27].
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In general, dependence receptors initiate cell death signals under stress conditions and reduced interactions of a ligand with its cognate receptor(s).
Since up-regulation of c-Cbl by over-expression enhanced association of c-Src with VEGFR-2, we further tested whether silencing expression of c-Cbl by siRNA would reduce interaction of SH2-Src with VEGFR-2.
Both DBT and TBT are much smaller than dexamethasone, which reduces interactions of these organotins with the GR.
One possibility is that CHD2 reduces interactions of non-nucleosomal H3 with naked DNA.
DNA could activate DCs by the TLR9 signal pathway to secret high levels of cytokines including IFN-α, IFN-β., The level of TLR9 expression was significantly downregulated in the pOVA + OVA co-treated DCs, which might reduce interactions of TLR9 and DNA to avoid the activation of TLR9 mediated signaling.
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