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Exposure to As from drinking water was associated with reduced intellectual function after adjustment for sociodemographic covariates and water Mn.
The researchers found that consumption of water contaminated by arsenic was associated with reduced intellectual function in a dose response fashion.
Exposure to As was associated with reduced intellectual function, in a dose response manner, such that children with exposures > 50 μg/L received significantly lower Performance and Full-Scale scores than did children with exposures < 5.5 μg/L.
Exposure to As from drinking water was associated with reduced intellectual function before and after adjusting for water Mn, for blood lead levels, and for sociodemographic features known to contribute to intellectual function.
Human exposure to lead contributes mainly to cardiovascular diseases, mild mental retardation from childhood exposure leading to reduced intellectual function, and additional outcomes which are more difficult to quantify [ 30].
Water As was associated with reduced intellectual function, in a dose response manner, such that children with water As levels > 50 μg/L achieved significantly lower Performance and Full-Scale scores than did children with water As levels < 5.5 μg/L.
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The World Health Organization Program for Chemical Safety Task Group on Effects of Inorganic Lead [ 48] reviewed all extant literature and concluded that blood levels below 25 μg/dL can reduce intellectual functioning in humans, with every 10 μg/dL increment predicting an IQ decrease of 1 5 points.
Children with specific learning difficulties (e.g. dyslexia) and reduced intellectual ability are more likely to experience anomalies of visual function than their peers [ 4].
Several groups, including our own, report significantly reduced verbal intellectual function and we also showed that specific language impairments occur in VPA-exposed children. 4 Meador's group also had a higher than usual rate of left handedness, which is associated with an increased likelihood of atypical (i.e. bilateral or right-sided) language representation in the brain.
If further study confirms the reversibility of adverse consequences after well mitigation, this might mean that well interventions delivered to very young children could have a significant impact on reducing negative impact on intellectual function.
Findings were independent of intellectual function, and functional MRI indices of language lateralization.
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