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Myocardial infarction afflicts close to three quarters of a million Americans annually, resulting in reduced heart function, arrhythmia, and frequently death.
Myocardial ischemic is a molecular disease of cardiomyocytes, but also, as a consequence of reduced heart function, becomes a disease of the whole organism.
Reduced heart function in the HART mice correlates with reduced expression in heart muscle cells of genes involved in the regulation of blood pressure, salt level, calcium handling and mitochondrial function.
The underlying cause of this precipitous drop characterizes shock; for example, hypovolemic shock is caused by inadequate blood volume, cardiogenic shock is caused by reduced heart function, and neurogenic shock and septic shock are caused by malfunction of the vascular system.
An appropriate screening procedure could be adopted, therefore, to identify 'at risk' patients with reduced heart function but no other signs of progressive heart disease.
Increased acute CVB3 myocarditis in males- compared to females was associated with reduced heart function with a lower ejection fraction by echocardiography at day 10 pi.
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Extended periods spent in microgravity are known to cause increased bone and muscle loss, reduced heart and artery function and impaired sensory motor performance.
These limitations were, for example, reduced heart or lung function, hearing impairment, and impaired balance.
Recently, our group demonstrated that after 15 days of MI, diabetic animals had reduced heart fibrosis, improved systolic function, and reduced infarct size.
Heterozygous dOpa1 Drosophila mutants also showed reduced heart rate, increased heart arrhythmias, and poor heart function as indicated by decreases in fractional shortening and increased heart failure in response to electrical pacing.
Impaired cardiac autonomic function, which manifests as reduced heart rate variability (HRV), may be one of the underlying causes.
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