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A non-consequential Leu157 to Ala (L157A) mutation that displayed much reduced foci formation and TfR binding had normal TfR distribution, normal surface TfR level and normal Tf internalization.
From this library gemcitabine (a nucleoside analogue) and chromomycin A3 (a glycosidic antibiotic) reduced foci in both DM1 and DM2 cells.
Ro 31-8220 and chromomycin A3 reduced foci numbers at concentrations that did not have a fully matching toxic effect although the viability of the cells was reduced relative to controls (Fig. 2A D).
Two compounds, chromomycin A3 from the NPC collection and Ro 31-8220 from the kinase inhibitor library, reduced foci in the primary screen and were validated in the secondary screen.
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When heart rate activity was high, infants may have reduced focus on the tasks, corresponding with reduced cognitive load.
In healthy folks, poor sleep is widely attributed to impaired memory, reduced focus, and poor emotion regulation.
Thus, we interpret our findings to indicate that compared to placebo MP reduced (focused) the use of attentional resources in the human brain that are necessary to achieve similar levels of performance on a task.
On implementation, our results revealed however, that there was reduced focus on counselling during HIV testing at the ANC settings.
We reduced focus drift by manually correcting it every 4-6 hours during the day and every 10 hours during the night.
To assess whether some VLT hits could reduce foci numbers, we performed a quantification of the number of foci in Drosophila by using fluorescence in situ hybridization (FISH).
However, aggregation cannot be the main cause of mortality, as interventions that reduce foci may not alter lifespan (Cohen et al., 2010; van Ham et al., 2010).
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