Exact(2)
In clinical practice, responses are primarily based on improvements in disease activity, especially reduced flares.
In another meta-analysis of trials from AS patients treated with TNF blockers, both infliximab and etanercept reduced flares of uveitis but infliximab was more effective [ 39].
Similar(58)
We found no significant difference in dermal NFD between those with PFN and control subjects; this finding suggests that the reduced flare reflects functional as opposed to structural impairment in the axon reflex pathway.
This suggests significant cost benefit to a gout disease management plan that has a goal of reducing flare frequency to fewer than 2 flares per year, and underscores the importance of prophylactic therapy to control sUA levels and reduce flares.
Traditionally, treatment of IBD has relied on corticosteroids to reduce flares and on immunomodulators to maintain remission [ 13].
Based on data from a small retrospective study and from one large but uncontrolled observational study [ 40], adalimumab seems to reduce flares of uveitis.
When it was investigated whether TNF blockers reduce flares or new onset of IBD in AS patients treated for their rheumatic manifestations, infliximab was clearly superior to etanercept whereas the number of patients treated with adalimumab was too small in this meta-analysis to allow any further conclusions [ 38].
More recently, atacicept is being evaluated in a double-blind, placebo-controlled, multicenter phase 2/3 trial to determine the most effective dose of atacicept for reducing flares (ClinicalTrials.gov NCT00624338), although it appears that the higher dose of 150 mg subcutaneously was deemed to have an unfavorable risk/benefit profile and is no longer enrolling patients (Table 1).
Keep the oil in the marinade to a minimum to reduce flare-ups and P.A.H. formation.
I didn't want to use olive oil (I wanted to reduce flare-ups, not encourage them).
Companies belonging to the North Dakota Petroleum Council announced the formation this week of a task force to increase efforts to reduce flaring.
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