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The reduced physiological reserve and reduced efficacy of pre-oxygenation in intensive care patients makes their intubation particularly dangerous.
However, the presence of HACA was not associated with IRRs or reduced efficacy upon retreatment.
Chemotherapeutic compounds are not effective against quiescent cells and therefore have reduced efficacy against tumors with extensive quiescence.
This disparity may reflect compromised fidelity of DSB repair in NBS cells rather than reduced efficacy.
A relatively long follow-up period might have reduced efficacy.
Some patients who developed AAAs demonstrated reduced efficacy.
An individual's genetic makeup may predispose the patient to these adverse effects and reduced efficacy.
Patients taking TNFi agents who discontinue concomitant MTX experience reduced efficacy and shorter responses.
Inactivated vaccines apparently have a similar safety profile but reduced efficacy in immunocompromised patients [ 39– 41].
Reduced efficacy of macitentan in the presence of rifampin should be considered.
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For a reduced-efficacy threshold of 90%, most combinations resulted in a reliable detection of reduced and normal efficacy.
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