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In both cell lines, increased [Ca2+]o and/or NPS R-467 reduced doubling time values.Treatment with NPS R-467 down-regulated CaSR mRNA expression in both cell lines.
Furthermore, a strain lacking the oxyR gene showed significantly reduced doubling times and a lower end-OD than the parental strain in anoxic conditions irrespective of iron availability (Table 2, Additional file 3: Figure S2).
Thus, although PTHRP-induced mitogenesis may occur through an ERK-independent mechanism, the ability of PTHRP to potentiate the activation of ERK by EGF and IGF-1, together with the ability of cells to respond to autocrine PTHRP, could provide one explanation for the increased mitogenic responsiveness and reduced doubling times of MCF-7 cells overexpressing the PTHRP-R.
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The city expanded its Sunday parking enforcement in 2002, saying the Sunday rules reduced double parking, congestion and pollution.
Weak ankle plantar flexors can cause a longer double support phase during walking, and a reduced double support phase was reported as a strong indication of improvement in movement stability.
Furthermore, the normal development of T cells was defective in these mice, with drastically reduced double positive mature T cells, which should normally express either CD4 or CD8 markers along with CD3 receptors for antigen.
MEFs lacking Ing1 or Gadd45a had a reduced, double knockouts an abolished potential to induce expression of the Mageb1– 3 genes and demethylation of the Mageb2 promoter upon UV-stimulation.
The ruling obsession was reducing double-digit inflation and cutting public spending.
The proposals included efforts to reduce double-digit inflation; tax breaks for education, housing and medical costs; and more spending for housing, infrastructure and military equipment.
In 2016, it released its first technical guidelines on how to measure podcast performance in order to create an industry standard and reduce double-counting.
Labour attacked the package as a "panic-stricken pre-election sweetener" while some economists questioned the lack of action to reduce double-digit interest rates.
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