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Reduced doses and more frequent dosing could dilute out the adverse effects and still produce some beneficial effects.
Reduced doses of these DPP-4 inhibitors improved glycaemic control in these subjects 42– 45, although comparisons of their clinical effectiveness with their respective standard dosing regimens are not available.
Reducing doses gradually can prevent this.
One persistent notion in many reviews of low-dose effects is the hypothesis of reduced biological effectiveness of fractionated low-dose exposures, compared to that of the same acute dose.
We evaluated the effect on model outputs of changing the time period for delivery of the first dose of vaccine to the entire population to two or six weeks, switching to a single vaccine dose, reducing vaccine effectiveness in the ≥65 age group (across a range of effectiveness of 30 60 percent), and varying the proportion of asymptomatic cases.
Hence, high doses (dose rates) actually reduce the effectiveness of angiostatin and produce a U-shaped dose-response curve.
Severe pain syndromes reduce the quality of life of patients with inflammatory and neoplastic diseases, partly because reduced analgesic effectiveness with chronic opiate therapy (i.e., tolerance) leads to escalating doses and distressing side effects.
This has severely reduced its effectiveness.
Most trials found that unexpected wind turbulence reduced their effectiveness.
And costs and risk can be reduced and effectiveness increased when several progressive companies act together.
While it is widely recognized that sub-optimal doses of vasodilators may have a limited effect, administration of high doses might also reduce their effectiveness because of counter regulatory mechanisms.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com