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Subtyping for emphysema using computerised tomography or reduced diffusion capacity would further refine the subphenotyping for COPD [78].
COPD patients had reduced diffusion capacity (DLCO), and increased hyperinflation (FRC, IC/TLC) compared to control subjects (P < 0.01), who all had normal lung function.
Additionally, reduced circulatory sRAGE levels are associated with more severe airflow limitation [ 8, 9], reduced diffusion capacity, and emphysema [ 6, 8] in COPD patients.
Low oxygen saturation or hypoxemia is associated with conditions or diseases involving ventilation perfusion mismatch in the lungs, hypoventilation, right-to-left shunts, reduced diffusion capacity, and reduced oxygen partial pressure in inspired air.
Spirometry revealed a reduced diffusion capacity and computed tomography of the chest was consistent with pulmonary fibrosis.
Spirometry has limitations in assessing the severity of pulmonary diseases, especially in the presence of reduced diffusion capacity as occurs in emphysema and interstitial lung disease.
Similar(53)
A wide range of potentially compensatory adaptations have been described in M/Mt-CK−/−(129/Bl6) mice to explain the mild early phenotype, for example, closer juxtaposition of mitochondria with myofilaments, thereby reducing diffusion distance [ 13], coupling of glycolysis with the SERCA pump [ 4] and increased mitochondrial capacity with flux through alternative phosphotransfer pathways [ 9].
Diagnosis is based on impaired diffusion capacity, reduced compliance of the lung and typical radiological findings.
Breathing carbogen is known to reduce diffusion-limited hypoxia.
Diffusion capacity (TLCO) reduced during treatment (P<0.0001), with a significantly lower drop in EC-GT patients (P=0.02).
Impaired diffusion capacity and the reduced forced expiratory flow between 25 and 75% of expiration (62.5 ± 25.0% of predicted at 12-20 months after hospital discharge) indicated residual changes in the small airways.
More suggestions(15)
reduced diffusion distance
reduced exercise capacity
reduced diffusion path
reduced diffusion coefficient
reduced diffusion length
reduced diffusion scale
reduced diffusion resistance
reduced diffusion barrier
reduced generation capacity
reduced diffusion anisotropy
reduced diffusion limitation
reduced management capacity
reduced flight capacity
reduced diffusion rate
reduced diffusion exponent
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