Sentence examples for reduced complement levels from inspiring English sources

19 20 Third, other factors associated with pSS, such as elevated levels of inflammatory cytokines and immunoglobulins and reduced complement levels, have also been linked to thrombosis.

Reduced complement levels were also associated with an episode of decreased degradation with OR 2.8 (1.3 to 5.7) for low C1q, 3.2 (1.6 to 6.5) for low C3 and 3.4 (1.4 to 8.3) for low levels of C4.

We also found that the NC16A2.5 pretreated mice had significantly reduced levels of BMZ-bound and circulating pathogenic antibodies and showed reduced complement activation, mast cell degranulation and neutrophil infiltration.

This may suggest that surface viscous forces play a role in reducing complement protein binding.

Earlier investigation had indicated that dextran-70 reduces complement-3 activation product levels during cardiopulmonary bypass [ 28], but subsequently it was revealed that fresh frozen plasma, which was applied in the control group in large volume, contains a high level of complement-3 [ 29].

Circulating levels of anti-HMGB1 antibodies had a fair degree of correlation with anti-dsDNA antibody levels and less pronounced, but statistically significant, correlation with disease activity markers such as classical complement activation, reduced levels of complement protein C4 and with disease activity index SLEDAI-2K.

Infants show reduced levels of complement components and complement activation [ 3] and increased levels of galectin-3 could very well play a compensatory role.

These include reports of patients with autoimmune diseases such as SLE and refractory autoimmune hemolytic anemia (chronic cold agglutinin disease) where beneficial effects of BTZ were accompanied by improved laboratory findings consisting of reduced anti-extractable nuclear antigen levels, reduced anti-double-stranded DNA antibody levels, and normalization of complement levels and platelet count.

In addition, this finding provides an explanation for the increased risk to develop SMA in infancy: children between 1 and 3 years constitutively express reduced levels of complement regulators on their RBC surface and therefore the probability to develop SMA is higher [40].

When the team tested blood samples from postoperative patients, whose wounded bodies were already scrambling to heal, they found that maggot secretions reduced the levels of complement proteins by 19% to 55%.

Further comparative studies investigating complement levels in invasive gray squirrels and other species could investigate the hypothesis that reduced investment in innate immune defenses may be driving this altered pattern of infection with B. burgdorferi sensu lato.