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The aim of the present investigation was to design a formulation with a considerably reduced coat weight and gum concentration for colonic delivery of 5-fluorouracil for the treatment of colorectal cancer.
Besides, the spin coating process enhanced solvent evaporation and reduced coat production time compared to the traditional by-hand casting.
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Results of this study provide a practical and effective way to operate CAE process with reduced substrate temperature, reduced coating roughness, and improved film adhesion.
However, there was hardly any microscopic failure observed on the surfaces of the multilayer coatings after tested in all chloride solutions, which is attributed to the combined effects including improvement in coating toughness due to the multilayer design and ZrN sub-layer, reduced coating stress, and good corrosion resistance from the ZrO2 sub layer.
Conversely, as fouling increases due to reduced coating efficacy, the demand for SR increases.
Dual loss of CD44 and RHAMM did not further reduce coat loss from that observed in CD44−/− MEF.
High external shroud gas flows had the most significant effect on reducing coating oxidation.
The results also revealed that presence of trace elements in the coating reduces coating life significantly.
This difference could cause deformation or cracking and reduce coating lifetime.
Pumping speed and dynamics, magnetron design, applied power waveform, target fabrication, gas distribution and the process control algorithms linking these components are all critical determinants in pushing the limits of sputter technology and reducing coating costs.
When applied to paper, the use of a cationic additive application specifically to the coating layer surface slowed down the ink penetration into the paper structure, by reducing coating permeability, and bound the anionic colorant at the top layer by charge interaction, so that reduced bleeding and improved water fastness could be achieved.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com