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Reduced clearance allows the use of lighter-grade oil.
However, whether the excess lipemia is associated with an impaired suppression of VLDL-TG secretion and/or reduced clearance into adipose tissue is unknown.
Another cause of lactate accumulation would be reduced clearance from CSF, but there is no evidence that changed lactate transport might play a significant role.
This capping is based in part on small trials which indicate reduced clearance of some chemotherapy agents in obese patients[21], [22].
Importantly, we show direct evidence from MCP-1 knockout mice, which exhibited reduced clearance of P. aeruginosa and increased pathological alterations in the lungs.
Reduced clearance has also been suggested in moderate hepatic insufficiency [ 121].
Patients with ESRD also have reduced clearance of insulin and certain oral hypoglycemic drugs used to treat diabetes.
Decreased ratios between urine urea/serum urea and urine creatinine/serum creatinine confirmed reduced clearance of these metabolites.
Preterm neonates and neonates in the first 10 days of life are even more prone to display reduced clearance.
By comparison, control transplants demonstrate reduced clearance of dopamine, confirming earlier observations in 6-hydroxydopamine lesioned animals models of Parkinson's disease (Cragg et al., 2000).
Use of ketoconazole reduced clearance of darifenacin by 68% (Kerbusch et al 2003) and increased the bioavailability of the drug to 100%.
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