Exact(57)
(e, f) Corresponding autoradiographs from (b) and (c), respectively, showing high uptake in all viable tumour islands, demonstrating that the apparent lack of uptake in macroscopically necrotic tissue is a function of reduced cell number rather than reduced antibody penetration or cellular uptake.
In three of these sera, mutation of residues at positions 876, 877, 878, 880, and/or residues 862 and 822 reduced antibody binding by more than 50%.
Whilst most published studies have shown reduced antibody uptake in necrotic areas, Boxer et al. found that, in some cases, patients infused with antibody to CEA had increased concentrations of antibody in necrotic more than viable areas of tumour [4].
This protein reduced antibody titer in mice immunized with BSA, significantly inhibited the killing of antibody-dependent cytotoxicity and CTL-mediated donor target cells, and reduced the expression of IL2 in mice.
The reduced antibody was stored at −80°C until use.
G106V significantly reduced antibody binding and neutralization whereas H317Q did not affect binding but did reduce neutralization by this MAb.
Inhibition with unlabeled GAD65 substantially or completely reduced antibody reactivity with both 125I Gand5 and with 125I GAD67.
Priming with only a single dose of DNA plasmid led to similar interferon-γ responses, but reduced antibody levels and less vaccine efficacy.
Similar(3)
There is promising therapeutic potential of TLR8 agonists in cancer, aiming to induce an immune response to tumors and improve clinical responses to clinically approved monoclonal antibody therapies, especially in individuals who show reduced antibody-dependent cell-mediated cytotoxicity activity.
Reduced and non-reduced antibody samples were resolved on SDS-PAGE (BioRad).
This product was then coupled to a pre-reduced antibody Fab' fragment (20 nmol) by mixing the purified Al18F-NODA-MPAEM at room temperature for 10 min, followed by isolation of the labeled Fab' by gel filtration.
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com