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Aging is typically associated with progressive multi-system impairment that leads to decreased physical and cognitive function and reduced adaptability to stress.
One of the study's researchers told LiveScience that the data doesn't necessarily verify that the disease is driving the decline, and other factors -- like reduced adaptability to environmental changes as a result of inbreeding -- are likely at play.
These changes are likely related to reduced adaptability associated with a stressed physiologic state and/or activation of the sympathetic response.
This is consistent with studies showing diminished genetic variability in natural populations resulting in increased genetic bottlenecks, inbreeding, reductions in effective population size and the potential for reduced adaptability and productivity (Hauser et al. 2002; O'Leary et al. 2013).
A possible hypothesis explaining the pathogenesis of the optic nerve head ischemia is that the AL-amyloid deposition found in the temporal artery specimen may also have affected the posterior ciliary arteries, causing arterial stenosis and insufficiency, or reduced adaptability to blood pressure variations.
Cellular determinants of reduced adaptability of the aging brain: neurotransmitter utilization and cell signaling responses after MDMA lesions.
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A dynamic self-organizing system must also strike a compromise between the over-stabilization of networks and the noise within and between various networks, as too much specificity reduces adaptability [ 5], whereas some reduced specialization provides a capacity for plasticity and adaptability.
Small, genetically uniform populations may face an elevated risk of extinction due to reduced environmental adaptability and individual fitness.
In addition, a null allele of the rice GI ortholog affected diurnal expression of 75% of all tested genes and conferred reduced seasonal adaptability in field grown rice [ 19].
However, the KEGG pathway database suffers from a number of limitations that reduce the adaptability of the pathways for automated analysis.
They can also have longer term consequences, if the loss of genetic variation through drift reduces the adaptability of the population to future environmental changes (Kinnison et al. 2007).
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