Increased proteolysis of newly synthesized proteins will result in reduced amounts and, in consequence, reduced activities of target proteins causing physiological imbalance and finally cell death.
Before formal approval, the researchers reduced activities on their PVD coating research and started work on the CVD process.
Biochemical studies showed reduced activities of complex I, III and IV in skeletal muscle.
Except for two mutants (Met5Leu and Met31Leu) with similar activities, seven mutants (Met73Leu, Met167Leu/Met169Leu, Met184Leu, Met220Leu, Met239Leu, Met244Leu, and Met239Leu/Met244Leu) were found to have reduced activities.
Thiamine (vitamin B1) deficiency (TD) produces a mild, chronic impairment of oxidative metabolism that models the diminished metabolism and reduced activities of the thiamine-dependent mitochondrial enzymes that occur in brain in several common age-related neurodegenerative disorders.
Reduced activities of hepatic alkaline phosphatase may lead to the breakdown of glycogen in order to get necessary energy to overcome the stress.
For reduced activities of daily living, the patient started rehabilitation, but at 1 month after the operation, the patient developed heart failure due to renal dysfunction with nephrotic syndrome.
Among these, about half display no or very low activity and the others, although they behave like native Gap1 in growth tests, display significantly reduced activities.
As shown in Table 1, in general, APE1 mutants exhibited reduced activities compared to the WT APE1 on all DNA substrates tested.
Cells from individuals with Friedreich's ataxia (FRDA) show reduced activities of antioxidant enzymes and cannot up-regulate their expression when exposed to oxidative stress.
The E4A4, Δ12-39 and KKAA Nef mutants displayed significantly reduced activities relative to wt Nef, however retained detectable Pak2 association.
