Results of this study indicate a low risk for reduced efficacy and reduced tolerability in patients with hepatic impairment.
This minor protocol violation was initiated during the course of the study, following up several patients who experienced reduced tolerability and side effects (nausea, diarrhoea) when immediately starting on 80 mg daily.
Underconjugation can decrease potency of the resultant ADCs, whereas overconjugation can lead to decreased circulation half-life, reduced tolerability, and impaired antigen binding.
Management of other comorbidities, common in older patients and in those with other risk factors, will likely involve treatment with other medications and the burden of polypharmacy or reduced tolerability through interactions cannot be discounted.
However, these early response data were not mirrored in the subsequent objective response rates, determined using RECIST version 1.0 (earliest possible confirmed response at 12 weeks); this may be because of the reduced tolerability associated with cediranib and the subsequent reduction in mFOLFOX6 dose intensity.
Rapid delivery of capsaicin may promote, rather than reduce, the tolerability of topical capsaicin.
Thus, newer compounds are needed that continue to improve convenience and tolerability, reduce toxicity, and improve antiretroviral activity, particularly against drug-resistant viruses.
The combination therapy did not reduce patient tolerance of the medications, and the combination regimen had higher tolerability ratings than tretinoin gel.
C-terminal truncation of both peptides reduced salt-tolerability of the microbicidal effect as well as anti-inflammatory actions.
Since cramping is felt to be a major component of discomfort during colon preparation [ 4], it was hypothesized that pre-treating the colon with a stool-softening fiber supplement could reduce cramping and improve tolerability.
