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The use of surrogate tissue-specific markers can reduce the specificity of the assays and give rise to a clinically unacceptable false-positive rate.
Another limiting factor to the use of 18F-FDG for assessment of cardiac sarcoidosis is that both inflammation and myocardial ischemia can increase glucose utilization and can further reduce the specificity of myocardial 18F-FDG uptake.
Despite this, in the case of the energy asymmetry method, saturation of signals contributes to reduce the specificity of the parameter and a slight degradation of the resolution can be expected at the boundaries of the DOI range.
Large necrotic tissues could have more false-positive uptakes of 11C-MET through variable factors mentioned above than small necrotic tissues, which could reduce the specificity of 11C-MET PET/CT.
Thus non-infectious exacerbations of asthma could cause chest symptoms and reduce the specificity of the CCQ.
These respiratory and cardiac fluctuations may reduce the specificity of low frequency fluctuations to functional connected regions [66].
Similar(37)
The achievement of Athill's work is its refusal to reduce the specificities of her captivating life to homilies about wisdom.
The authors proposed that AV-45 ROI SUVr included local non-specific white matter uptake, reducing the specificity of the findings compared to PiB in patients.
The underestimation of Simple forms reduces the specificity of the test; however, it makes possible to have a high sensibility, reducing the number of false positive cases.
Pretreatment actually slightly increased the number of false positives, reducing the specificity of pretreated smears (92.6% [87.1 96.4]) as compared to direct aurmine smears.
Although this probeset could be used to construct a classifier with a reasonably large margin, the presence of a sample of normal tissue with expression close to the cancer group drastically reduces the specificity of a classifier based upon this probeset.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com